Going from a Drug Search into Bio to Find Similar Sequences

In this workflow, we conduct a drug search for a target in Synapse and then proceed to the Bio platform to locate similar sequences for that drug.

To begin, go to the Synapse homepage, enter the target name "LAG3" in the search box, and select the name under the "Target" section in the dropdown menu:

Upon clicking the blue "Search" button, you will be directed to the results page, offering extensive information on the target "LAG3," including news, literature, clinical results, and more. Since we are interested in finding drugs, click on the "View all Drugs" button:

Once you've reached the Drug results page, select a drug name to access its detailed information. As an example, we will be exploring the Drug Tebotelimab:

You'll discover comprehensive drug information here, including synonyms, clinical trial results, R&D status, and more. Scroll down, and you'll often find the biological sequence or chemical structure, particularly for small molecule therapeutics. This is great because it provides a direct link to both our Bio platform and our Chemical platform, depending on the drug type. So, if this is something we want to search for in Bio or Chem, or perhaps we want to explore similar structures, it's just one click away.

In this workflow, our goal is to find similar sequences to the drug sequence. To do so, click on the "Find Similar Sequence" button next to the first sequence:

This will take you directly to the Bio platform where you can adjust/change the search parameters before conducting the similar sequence search:

There are no hard and strict criteria for when the sequence becomes available to view for a Drug. As soon as it hits phase two or phase three, we immediately have it. It does, however, depend sometimes, as some variance does exist. We source information from different sources so we take a look at information disclosed within the clinical trials as well as any associated patents that we have tagged to the drug record.

After conducting the sequence search, you can continue with other workflows, for example, finding patents and literature relevant to the sequence, setting up email alerts, saving the sequence to a Workspace, etc.