Translational Medicine Search

Background Information

Translational research, also referred to as translational medicine or translational science, refers to the “bench-to-bedside” process that harnesses knowledge from basic scientific research into clinical research to create novel treatments and treatment options devices, medical procedures, preventions, and diagnostics. The purpose of translation medicine is to form a bridge between basic research and clinical research.

The T0 to T4 classification system is a way to describe where research sits on the translational science spectrum. It allows us to better track our research portfolio along the entire research continuum, from basic research to community health.

• T0 Research: basic biomedical research, including preclinical and animal studies.
• T1 Research: translation to humans, including proof of concept studies, Phase 1 clinical trials, and focus on new methods of diagnosis, treatment, and prevention in highly controlled settings.
• T2 Research: translation to patients, including Phase 2 and 3 clinical trials, and controlled studies leading to clinical application and evidence-based guidelines.
• T3 Research: translation to practice, including comparative effectiveness research, post-marketing studies, clinical outcomes research, as well as health services, and dissemination & implementation research.
• T4 Research: translation to communities, including population-level outcomes research, monitoring of morbidity, mortality, benefits, risks, and impacts of policy and change.

Synapse's Translational Medicine Search

The Translational Medicine search can help pharmaceutical companies efficiently search for important translational medical literature research and find new opportunities. You can access the search by clicking on the "Search" button located in the left-hand sidebar and then selecting "Translational Medicine":

The search tool covers over ten dimensions such as drugs, targets, indications, subjects, publication date, journal conferences, etc.

The following are the definitions of each research "Subject":

1. Epidemiology: Statistics on the incidence, prevalence, and causative factors of diseases among different populations. For example: Study on the incidence of non-small cell lung cancer in UK.
2. Pathogenesis: Explain the mechanisms of disease development at the molecular level. For example: Deletion of the DOCK gene causes systemic inflammation.
3. Target/Biomarkers: Study the effect of gene or protein regulation on disease intervention. For example, activating the STING pathway can be used for tumor treatment.
4. Structural Biology: Use physical means to analyze the structure of proteins or protein-ligand complexes and study the relationship between protein structure and function.
5. 1/2/3 clinical studies post-marketing studies: Drug clinical trial results.
6. New Technology: Drug-related technologies, mainly introducing new drug modalities, drug modifications, drug delivery, and the principles, methods, and effects of drug manufacturing technology.

Once you've finished your search, simply click the blue "search" button to proceed to the results page. Here, you'll find a wealth of information, including details on drugs, targets, indications, subjects, publication dates, and the relevant journals or conferences. You can access the original articles directly by clicking on their titles.

After selecting the "Table view" option, you'll find a section labeled "Highlight" that utilizes our LLM technology to distill research content, providing a concise overview of the research status for easy comprehension.

If you're interested in clinical trial research literature, you'll find a link that leads to detailed clinical results presented in a tabular format, allowing you to easily view key data.

Within the "Analysis" tab, the following three charts are available:

1. Research trend: Aggregate the top-ranked targets, indications, and drug types in translational medical literature by publication year to understand research trends.
   
2. Research Direction: Conduct a cross-analysis of targets, indications, and drug types to understand the direction of research.
   
   
   
3. Active Organizations: Rank research institutions based on the number of translational medicine literature and discover leaders in current field research.
   

You are able to export the chart as well as other data in the "Table" or "List" view by clicking on the "Export" button: