Antibody-Target Predictor (AI Agent)

What is it?

The Antibody-Target Predictor AI Agent is a powerful tool designed to validate and screen antibody-target relationships to accelerate candidate selection in the antibody development process.

By leveraging curated antibody R&D content—including antibody-antigen pairings, epitopes, sequences, and affinity data—the AI Agent helps teams predict and rank antibody candidates, enabling faster, more confident decisions while reducing development risks and costs.

Who is it for?

This tool is purpose-built for:

• Antibody R&D teams

• Antibody Discovery and Screening specialists

• Biologics, monoclonal antibody (mAb), and Antibody-Drug Conjugate (ADC) biopharma companies

• Sequencing CROs working in the antibody development space

How does it help?

Traditionally, screening antibody sequences for freedom to operate (FTO) and drug target data is manual, slow, and high-risk, often taking weeks or months with uncertain results. This AI Agent:

• Automates the antibody-target validation and ranking process

• Reduces costs associated with high-throughput (HTP) screening and manual evaluation

• De-risks downstream development by helping teams avoid poor antibody candidates early

• Saves costs versus outsourcing to providers like mAbsilico (where one search may cost €7,000 and take 2+ weeks)

Key Features & Workflow

Here’s how the Antibody-Target Predictor works:

1. Input
   
   

   • Required: Target (name or UniProt ID)

   • Optional: Antibody sequences

2. Automated Data Retrieval

   • Searches internal antibody R&D data for matches to the target

   • Performs BLAST search to find similar antibodies (if sequences provided)

3. Affinity Scoring
   

   • Retrieves available antibody-target affinity data

   • Ranks antibodies based on affinity scores

4. Comprehensive Ranking
   

   • Uses affinity, epitope binding, and sequence similarity to produce a robust shortlist

5. Final Output
   

   • A Shareable report with:

     • Top 5 antibody recommendations

     • Affinity and epitope analysis

     • Optimization suggestions

Current Limitations

• No data export functionality

• No hyperlinking back to Synapse or Bio Antibody R&D platforms

• Not currently trained on Synapse data

• Does not provide therapeutic ranking