Workflow - FTO Searching for Generic Pharma

What is Patsnap Chemical?

Chemical technology encompasses a wide field of study, covering areas including, petrochemicals, pharmaceuticals, cosmetics, material science, ingredients and more.  Chemical by Patsnap enables exact and similar structure, substructure, and superstructure searches. It combines these with Patsnap’s comprehensive global patent coverage, which includes full-text coverage for more than 60 countries.  It enables users to augment searches with a wealth of additional knowledge, including legal and litigation data, licensing and grant information, latest scientific research, as well as relevant company information.

FTO Searching for Generic Pharmaceuticals

To start, it is important to identify the relevant active ingredient or drug (1), then begin searching for similar compounds.  This can be done in Patsnap via numerous recognized labels that these structures have.  

Once the structure of interest is identified, the next step is to define the scope of the search (2).  Looking for similar structures requires the selection of Similarity Search, as well as an allowed variation in the Tanimoto Scale.  Varying by application, looking for similar compounds can be achieved by clicking Search Structures (3).

Once a list of pertinent structures is identified, the results can be viewed in the Chemical Landscape (Chemscape) to gain a strategic perspective of the compounds of interest. The Chemscape shows the structures from the initial search results, organized in proximity to each other based on the Tanimoto Scoring scale as well more advanced metrics defined by Chemical Hashed Fingerprints. 

Once in Chemscape, navigate to find structures associated with pre-standing regulatory approvals (4).  The highlighted columns reflect the structures with the associated selected approvals – clicking on one (5) will bring up a pop-up window on the right of the screen with information regarding that selected structure (6).  The number of patents associated with the structure is hyperlinked, and clicking on it (7) will lead directly to the patent results page in Chemical.

Once on the results page, open the results in analytics (8) and filter the gathered results to show Active/Pending (9) patents and those with family representation in our jurisdictions of interest (10).  Additionally, it is also possible to identify relevant patent documents by further refining using keywords through searches in the claims (CLMS) or title/abstract/claims (TAC).

Once the list of results has been gathered, the patents can be read through, and the use of the Structure Assistant within the patent view will allow users to directly identify where the selected molecule is being referenced throughout the patent text.