Reshaping sequence analysis with the new Bio modification search

We're excited to launch a first-of-a-kind tool for searching sequence modifications in Patsnap Bio!

 

Whether you're a scientist or a patent professional, Bio's new modification search tool can help you uncover key sequence modification patterns to optimize therapeutic development and fuel innovation.

 

Sequence modification, which involves adding chemical groups to specific sites on a protein or nucleic acid sequence to induce functional changes, is central to drug development and intellectual property (IP) protection. Modifications like fluorescent labeling, glycosylation, and phosphorylation are just a few of the many modification techniques available to achieve optimal therapeutic properties, such as high bioavailability and target specificity, extended half-life, and reduced off-target effects.

By understanding common modification patterns and their impact on therapeutic efficacy and patentability, you can more easily navigate the complexities of therapeutic development. 

 

The new modification search enables you to search for site-specific modifications, with or without a query sequence, by drawing from a library of over 1.5M modified sequences standardized using AI and manual curation. With modification search, you can now answer essential questions regarding specific modifications, such as: 

• How widely is this modification used?   
• What existing prior art contains this modification? 
• What other modifications are related to my query? 

Key Features

• Standardized modification library: Leveraging advanced AI and meticulous manual curation, we've consolidated sequence modification data into a standardized library that includes nine major categories and 382 subcategories of chemical modification types. 
• Flexible search options: The search tool offers both a sequence-based and sequence-free search option to dive deep into a specific modification. For a sequence-based query, up to 200 target sequences can be searched at once using local or global alignment methods.

• Visualize modification trends: Equipped with robust visualization tools, Patsnap Bio helps you explore the distribution of chemical modifications within your search results related to your queried sequences or modification types.
• In-depth source analysis: Identify new opportunities and assess patentability of inventions by quickly accessing the corresponding patents to your search results and diving into the modification claims.
• Instant modification report: With just one-click, generate exportable reports summarizing the distribution of hit modifications, as well as a summary of all other sequence modifications within a result set to expedite further analysis and decision making.

Want to see the modification search in action? Contact our team to discuss upgrade options or book a demo for your team today!